Thirteen-year-old Meredith yearns to become a teacher but must leave school to help support her family. To find the best paying job for a young girl of her class, she travels to the city to work as household help in a doctor’s home. From the start, her life is made difficult by the cantankerous and prickly butler, and confrontations with Maggie, the doctor’s spoiled thirteen-year-old daughter.
As the deadly Spanish Flu sweeps across the city, members of the household fall ill one by one. With the doctor working night and day at the hospital, only Meredith, Maggie, and Jack, Maggie's handsome older brother, are left to care for them. Every day the newspapers’ lists of “Yesterday’s Dead” add to Meredith’s growing fears.
When Jack becomes gravely ill, Meredith must stop fighting with Maggie so they can work together to save him. As Meredith wrestles with questions of duty and responsibility, she opens the door to a future that she thought had been closed forever.